Question 01:

In classical PKU:

Phenylalanine dehydrogenase is deficient
The biochemical deficiency in PKU interferes with the conversion of phenylalanine to tyrosine
The co-factor tetrahydrobiopterin is deficient
Phenylalanine hydroxylase is not deficient
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Explanation

The enzyme phenylalanine hydroxylase, which converts phenylalanine to tyrosine is deficient in classical PKU. The co-factor tetrahydrobiopterin is not deficient in classical PKU. There is no enzyme called phenylalanine dehydrogenase.

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